Leigh Zachary Bursey Community Advocate Young Leader Impactful Actions Award Finalist
International best-selling author, loss prevention officer, research consultant, supportive housing program coordinator, community organizer and journalist. Through these roles, Leigh Zachary Bursey has engaged with vulnerable people and worked to amplify their voices to produce social change.
Leigh has never shied away from tackling challenging social topics such as homelessness, mental health, harm reduction and allied support for the LGBTQIA – and for him, this work is personal. “My mother and I dealt with homelessness while I was in high school, giving me an early education in trauma and desperation,” notes Leigh. “As a result, I understood early on that I wanted to help people.”
It was while standing calf-deep in snow at a bus stop in Brockville, Ontario and realizing that this was a daily experience for many people that Leigh decided to run for city council. “I used my punk rock ethos, music background and big mouth to go out and make a difference,” says Leigh.
During his three terms as Brockville city councillor, Leigh participated in important discussions about social justice issues including gender equity, homelessness, mental health, harm reduction and affordable housing. “I was tagged as the punk rock councillor and was called by people in crisis to help. That experience provided powerful, hands-on experience in dealing with the circumstances and traumas of others,” he said.
Leigh’s passion for community development and helping those who are often marginalized and in need of support is reflected in his work. In addition to his role as a city councillor, Leigh has served as Vice-President of the Ontario Non-Profit Housing Association, and as a Child Protection Support Worker for Family and Children Services of Lanark, Leeds and Grenville, and for Cornerstone Landing Youth Services in Lanark County. He has worked in youth homeless shelters and adult warming centres, advocating for naloxone training and increased harm reduction supports, and has been a vocal supporter of increased public transit hours and of adding operating dollars to local library budgets.
A highlight of Leigh’s career was speaking at the International Journal on Homelessness Symposium in Chicago in 2023. “I presented case studies that told the stories of rough sleepers – putting a name and a face to homelessness. Some of the rough sleepers I’ve worked with are the most incredible people I’ve known. I have come to understand that my lived experience is trivial in comparison,” says Leigh.
Leigh has shared his research findings as a frequent presenter at national conferences including the Canadian Rural and Remote Housing and Homelessness Symposium, the Canadian Alliance to End Homelessness Conference, the Canadian Association for Suicide Prevention National Conference and the Canadian Housing and Renewal Association National Congress.
The focus of Leigh’s work has been to represent marginalized people in order to communicate their challenges and share their ideas for change to develop scalable solutions that can be replicated across borders. He has challenged stigmas and amplified the voices of the people he works with through outreach and engagement. “When asked what I do, I often say that I love people who are sometimes hard to love,” says Leigh. “I encourage people to make better decisions.”
Leigh’s dedication to advocating for the most vulnerable in the community is exemplified by his philosophy in life: “Kindness is free and a very underutilized form of currency that we should all exhaust.” Profound Impact is honoured to share the story of Leigh’s work and its impact and to recognize his accomplishments as an Impactful Action Awards finalist in the Young Leader Category.
You can see more about Leigh’s career and impact in the visualization below.
Do you have an impact story to share? Let us know at connections@profoundimpact.com for a chance to be featured in an upcoming newsletter!
Lynn Smith
Regional Planning Coordinator
Lifetime Achievement Impactful Actions Award Finalist
Lynn Smith has fond memories of walking through the jack pine forest of the Peavine Métis Settlement in northern Alberta, of which she is a proud member, with her grandmother to pick blueberries and of camping with her family in those same forests. In her current role as Regional Planning Coordinator within the Consultation Department in the Settlement, developed in partnership with NAIT (the Northern Alberta Institute of Technology), she is leading her community through a significant change to take control of monitoring the impact of climate change on their land and waterways.
“Indigenous people have been stewards of the forests and waterways for generations,” notes Lynn. “I am now in a position to make changes to bring things back, as closely as possible, to the way they were when I was a child, when my cousins and I could drink directly from the river and streams in our community.”
Lynn works with compassion and perseverance in collaboration with community members to build knowledge and achieve data sovereignty in order to better hold industry and all levels of government accountable for how their actions impact Indigenous lands. She has developed an environmental monitoring program managed by a team of community-based environmental monitors and data technicians that deliver real benefits to the Settlement. This mentoring model ensures that the skills of those monitors and technicians are retained within the community.
Lynn regularly initiates, enables and sustains collaborations with a broad range of stakeholders, including Elders, traditional hunters and fishers, NAIT staff and students, all levels of government, and companies from the energy, forestry, and environmental consulting sectors. She reaches out to people and organizations with different experiences and expertise and enables her team to weigh in on decisions to achieve her community’s goals – all while demonstrating her compassion and strong interpersonal connections.
Although Indigenous peoples own, occupy, or use about a quarter of the world’s surface, they safeguard 80% of the world’s biodiversity. Attempts in the past by those communities to set up environmental monitoring programs have suffered from a lack of knowledge, thereby hindering the development, sustainability, quality and viability of the programs. Lynn has developed innovative partnerships between the Indigenous community and Western scientists, to teach Indigenous ways of knowing and to share Western-based methods of doing science with professionals who create environmental monitoring programs in her community. Lynn is also breaking new ground by communicating her learnings in setting up environmental monitoring programs to the scientific community by participating in the upcoming Chemical Society of Canada conference – a first for a non-traditionally trained scientist.
The sharing of knowledge and learnings with other Indigenous communities suffering from similar environmental challenges is a vital element of Lynn’s work. She works with communities to build competencies in their consultation teams to autonomously monitor their land, generate and interpret data, and implement management programs.
Lynn has been recognized for her achievements by being asked to represent her community on the Board of Directors of the Lesser Slave Lake Watershed Council, which works to improve and maintain a healthy watershed through education, planning and implementation of shared initiatives supporting communities and ecosystems throughout the region.
Lynn is mother to three young adult children and, when not working for the Settlement, owns and operates, along with her husband, Jesse Smith, three businesses: P’J’s Eavestroughing, Lynn and Jesse Grain Farm and D’Vine Trap Range. The trap range evolved from her love of the sport of trap shooting, where she was named the 2019 Canadian Ladies Champion. She is currently and has been, for the last 5 years, the reigning Alberta Provincial Ladies Champion.
“I’ve never thought of myself as a pioneer,” says Lynn about her work. “This is the best job I’ve ever had!”
Profound Impact is delighted to showcase Lynn’s important work and its incredible impact on the Peavine Métis Settlement and across Indigenous communities.
You can see more about Lynn’s career and impact in the visualization below.
Do you have an impact story to share? Let us know at connections@profoundimpact.com for a chance to be featured in an upcoming newsletter!
November was a busy month for the Profound Impact team as we released our annual Social Impact Report, participated in industry conferences and met with venture capitalists in the US in preparation for the company’s next funding round.
The Profound Impact Social Impact Report highlights strategies we’ve undertaken over the last twelve months to maintain and improve a positive environment for our employees. These initiatives have included monthly in-person team meetings, team-building activities, virtual social events (including group cooking sessions), group volunteering, professional skills and growth support education programs, a team-wide book club and the matching of charitable contributions to community organizations. I’m proud to report that Profound Impact has achieved an employee retention rate of 100% (with 0% attrition) while growing the team by 33%. This employee retention rate is in stark contrast with tech companies globally, where the average attrition rate sits at 13.2%.
Conference attendance and presentations took Profound Impact employees across North America to learn more about key technologies and to meet current and potential customers.
Our Technical Program Manager, Sohail Ramzan, attended AWS Reinvent in Las Vegas to meet with AWS experts and to learn about the latest cloud industry innovations and how generative AI is revolutionizing the workplace.
Sherryl Petricevic, Director of Strategic Alliances and Partnerships was joined by Mike Folinas, Director of Research Administration at the Leslie Dan Faculty of Pharmacy, University of Toronto to present a case study on the use of Profound Impact’s Research Impact tool at the Canadian Association of Research Administrators (CARA) East in London, Ontario.
Jacqueline Watty from our Business Development team represented Profound Impact at qConnect 2023 in Calgary to connect with researchers and industry representatives discussing Canada’s role as a leader in quantum research and development, and how and why quantum is going to affect, change and benefit businesses.
Karl Burger, Director of Sales, attended the VentureLAB HardTech Summit, Canada’s premiere technology and innovation-focused summit that brought together global industry leaders, Canadian founders, investors, and innovators to explore the necessary ingredients to build a strong, connected hardware and semiconductor ecosystem in Canada.
Dr. Deborah Rosati, the chair of Profound Impact’s board of directors, and I took part in Pathways to Silicon Valley, where 24 female founders from across Canada participated in a curated immersion program designed for women founders of start-ups on their path to global business growth. We joined this program to establish relationships with US venture capital firms to prepare for our next fundraising round and our launch into the US in 2024.
December is the season of giving and the team at Profound Impact is demonstrating the power of small acts of kindness through our annual 12 Days of Impact, a program that encourages generosity. Our 12 Days of Impact campaign provides great examples of easy and inexpensive ways to be kind and generous and has also helped members of the Profound Impact team create a meaningful sense of contribution to their community while increasing bonds of collegiality on the job. We encourage you to download the 12 Days of Impact calendar and challenge your team to participate through small acts of kindness that have great big impacts.
I wish you all the best for 2024 and look forward to working with you in the new year.
Tabatha Laverty Vice-President, Marketing and External Relations, Accelerator Centre Young Leader Impactful Actions Award Finalist
It was during a Grade 8 field trip to a television station where a classmate’s father worked that Tabatha Laverty decided that she wanted to be a journalist. “I really didn’t consider another career until I graduated from Seneca College’s Television Broadcasting program, just as journalism as a business model was changing,” says Tabatha. “I realized that there wasn’t as broad of a variety of career options as I would have liked and ended up at a Big Four accounting firm, working in administration and marketing.” She was drawn to the storytelling aspect of journalism and discovered that marketing and communications would offer her the opportunities to tell those stories.
Tabatha’s career journey from project management, marketing, communications and community engagement to her current role as an acclaimed non-profit leader and award-winning marketer has seen her develop a passion for workplace equity and inclusion and an understanding of the vital importance of mentorship.
As VP of Marketing and External Relations at the Accelerator Centre in Waterloo, Ontario, Tabatha has spearheaded the organization’s EDI Action Plan, resulting in significant progress in creating a more inclusive and equitable innovation organization and tech community ecosystem. Most significantly, when women-led start-ups account for approximately 17.5% of all private-sector businesses in Canada, over 63% of the Accelerator Centre’s most recent program launch are women-led businesses, with 26% being led by newcomers to Canada, and 5% by indigenous entrepreneurs.
Tabatha was also instrumental in developing the Accelerator Centre’s cleantech incubation program, a first for Waterloo Region. In 2020, the programming was expanded to support all entrepreneurs working on solutions that support the achievement of the UN Sustainable Development Goals, adding resources for med-tech, ed-tech, smart city and social innovation-focused start-ups and supporting nearly 100 start-up companies.
Tabatha’s commitment to the advancement of women in the workplace includes her participation in the Waterloo Region Chapter of Women in Communications and Technology (WCT-WR) as a board director. “I love this community. The Kitchener Waterloo area has been such an incredible place for my family to live and work, and I’m passionate about giving back. Serving on the WCT-WR board is one way I can do that. I look forward to doing amazing things with this incredible organization and increasing access to networks, mentorship, and community for women across the region,” says Tabatha.
In addition to her role on WCT-WR’s board, Tabatha serves as a mentor in the organization’s Mentoring Circles program. She participates in monthly meetings with a fellow mentor and 5-6 mentees in similar career stages to share stories, provide guidance and help build mentees’ skill sets. “Mentoring is very important,” notes Tabatha. “It’s essential to reach out to people who have accomplished something you want to accomplish. And it’s important to get out of the echo chamber by including mentors from different backgrounds. For me, that was learning about finance, strategy, and EDI from people more accomplished in those areas than I am.”
In addition to the wisdom gleaned from her mentors and career champions, Tabatha has broadened her skill set through post-graduate certificates in social media management, fundraising, digital marketing, stakeholder management and non-profit and voluntary sector management. As a wife and mother of three, Tabatha prioritizes making time for herself and her family. “I wouldn’t say I am an expert in work-life balance, or that I have it figured out,” she says. “But I am lucky to work at a place that values flexibility, and I do my best to find a balance that works for me and my family.”
In 2021, Tabatha received the Global Women in Leadership Award issued by the Global Council for the Promotion of International Trade and, in 2022 was nominated for DMZ Women of the Year Award. Profound Impact is proud to have designated Tabatha as a finalist in the Young Leader category for this year’s Impactful Actions Awards in recognition of her work as an accomplished leader and active community champion.
You can see more of Tabatha’s career and impact in the visualization below.
Do you have an impact story to share? Let us know at connections@profoundimpact.com for a chance to be featured in an upcoming newsletter!
Stephanie Thompson, P. Eng General Motors Lifetime Achievement Impactful Actions Award Finalist
“Be a ladder, be a lamp or be a lifeboat.” This is Stephanie Thompson’s motto in her work as a passionate engineer and community leader who increases awareness for engineering, manufacturing and skilled trades careers for young women.
Stephanie grew up as the oldest of four children in Ottawa. Her interest in a career in science was sparked by an invitation by Mrs. Williams, her Grade 11 physics and chemistry teacher, to an overnight trip to the Chalk River Laboratories in Deep River, Ontario, where she saw nuclear physicists at work. “My teacher had a profound effect on me by recognizing my potential in science,” says Stephanie.
Stephanie liked chemistry and chose to study chemical engineering at the University of Waterloo after doing her research and learning that engineers had the best capacity for earning. Although successful at the traditional model of learning in high school, she found university to be humbling. “I had to figure things out. How to be creative and inventive and how to learn. And this prepared me for work after graduation,” she notes.
During her 22-year career at General Motors in St. Catharines, Ontario, Stephanie has worked in a range of engineering roles, including Launch Process Engineer, Process Engineer and Production Group Leader, and was the first woman to serve as an Engineering Manager. “I have been most successful when surrounded by talented and smart people, allowing me to find my space in a way that nobody else was doing.”
Through her extensive community outreach, Stephanie promotes engineering and other STEM fields as a storyteller, problem solver and a breaker of barriers. It is through these skills that she allows others, especially women, to see what they do not see in themselves.
In 2019, Stephanie launched the social enterprise STEM by Steph. STEMbySteph.com offers a range of activities, including a workshop series that brings women together to explore STEM careers. These workshops are led by women and focus on topics including Chemistry, Automotive, Environment, Space, Robotics, and Electrical. STEM by Steph also offers pro-bono career coaching for high school students.
Stephanie believes that a major barrier for girls pursuing trades and STEM fields is the lack of female STEM role models. In response to that need, STEM by Steph workshops offer a frequently sold-out social event where other female STEM professionals join Stephanie to teach young women and their mothers in a fun, camaraderie-filled atmosphere. “If you want more young women to be interested in non-traditional roles, involve their mothers,” notes Stephanie. “You cannot be what you do not see, and a major influence in every girl’s life is her mother.”
As a FIRST Robotics Mentor, Stephanie has run FIRST Robotics teams at local schools since 2005 including leading the Niagara FIRST Lego League as Tournament Director. She recently connected engineers and electricians from General Motors with over 200 students from across Ontario for a day-long workshop on Design Thinking about the future of automotive.
In addition to her mentoring and community outreach work, Stephanie is active in the Niagara Region as a member of the Brock University Board of Trustees, a member of the Niagara College Industrial Automation Program Advisory Committee, the inaugural Chair of the Brock University Engineering Industry Partners Committee and Director of Innovate Niagara.
Stephanie’s professional and community work has been recognized by the Greater Niagara Chamber of Commerce as the 2018 winner of the Women in Business Award for Science and Technology. She was awarded the 2020 Alumni Achievement Medal for Community Service by the University of Waterloo and was included in the Top 100 Most Powerful Women in Canada in 2020, 2021, 2022 and 2023, when she was inducted into the Hall of Fame
Stephanie’s impact on the community is perhaps best summarized by Nancy Watt, Advisory Board member for the internationally recognized magazine, Enterprising Women. “When I asked Stephanie to help build a STEM event on behalf of the Young Enterprising Women Foundation, I had no idea she was about to deliver a record-breaking, precedent-setting, multi-media-covered event that garnered an article in Enterprising Women. Stephanie is a connector. She sees potential and opportunities in others, puts them together and watches synergy take hold. She puts forward-thinking strategy to use, analyzing and achieving the best possible outcome for those who know her.”
You can see more of Stephanie’s career and impact in the visualization below.
Do you have an impact story to share? Let us know at connections@profoundimpact.com for a chance to be featured in an upcoming newsletter!
We’re excited to make innovation in medicine the focus of this month’s newsletter and to introduce you to two Canadian trailblazers who are making profound changes in the treatment of diabetes and gynecologic cancers.
Our November Impact Story features Dr. Harald Stöver, Professor in the Faculty of Science at McMaster University and founder and CEO of Allarta Life Science. You’ll learn how Harald has moved his research on polymer hydrogels, bio-relevant macromolecules and the delivery of biologics from the laboratory to market to fundamentally change the way that patients with Type 1 Diabetes receive treatment.
You’ll also meet Dr. Laura Hopkins, a gynecological oncologist with the Saskatchewan Cancer Agency and Professor in the Division of Oncology and Provincial Lead for Gynecologic Oncology. A dedicated clinician, Laura’s devotion to providing excellent and timely care for patients through all stages of cancer treatment has led to the launch of the Saskatchewan Cancer Agency’s first investigator-initiated trial to explore patients’ preferences for precision medicine in ovarian cancer.
In keeping with the focus on medical technology innovations, this month’s Research Spotlight explores technologies that are providing advanced tools that, thanks to innovative research partnerships between clinicians, scientists, patients and industry, are vastly improving patient care and clinical outcomes.
This month’s newsletter also features an article about CANARIE, Canada’s National Research and Education Network, in recognition of its 30th anniversary. Along with its provincial and territorial partners, CANARIE operates NREN, Canada’s National Research and Education Network. This nationwide, ultra-high-speed network connects Canada’s researchers, educators, and innovators to each other and to global data, technology, and colleagues.
In late October, I was appointed as Vice-Chair for the CANARIE Board. I am extremely honoured to take on this role and have the opportunity to work closely with the Board Chair, Larry Rosia, President and CEO of Saskatchewan Polytechnic, Past Chair, Sylvie LaPerriere and the other Board members. As the CEO of a female-founded company, I’m proud to serve on the board of an organization committed to diversity as reflected in the appointment of Kathryn Anthonisen, CANARIE’s first female President and CEO, and, when women occupy just 23% of board seats in Canada, a board that is 60% female.
Thank you for connecting with us and the Profound Impact community.
Direct-to-consumer genetic testing, affordable virtual reality gaming for home use, AI-enabled home appliances and mRNA vaccines developed in quick response to a global pandemic have become part of daily life.
These technologies are among those revolutionizing the way healthcare is delivered and are giving rise to innovative and productive collaborations between clinicians, biologists, computer scientists and industry.
mRNA Technology
In 2023, the Nobel Prize in Medicine was awarded jointly to Katalin Karikó and Drew Weissman for their discoveries that enabled the development of effective mRNA vaccines against COVID-19. As noted by the Nobel Prize organization, “Through their ground-breaking findings, which have fundamentally changed our understanding of how mRNA interacts with our immune system, the laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times.”
Although messenger RNA, or mRNA, was discovered in the early 1960s and research into how mRNA could be delivered into cells was developed in the 1970s, it wasn’t until 2020, when COVID-19 became a global pandemic, that the first mRNA vaccine was made widely available. Thanks to advances in nanotechnology, where lipid nanoparticles were developed to wrap mRNA and allow entry into cells, the first mRNA vaccines were developed against the Ebola virus. This milestone, combined with decades of research and huge increases in funding released during the pandemic, allowed for the worldwide release of the first mRNA COVID vaccine.
Because mRNA vaccines are made in a lab using easily available materials, these vaccines are developed quickly and can be tested via large-scale clinical trials to demonstrate their safety and effectiveness. These vaccines can also be quickly modified to address new virus variants.
The ability to quickly develop very effective vaccines through the use of mRNA for COVID has spurred the development of additional mRNA vaccines for use in HIV, flu, Zika, rabies and to trigger the immune system to target cancer cells.
Virtual Reality/VR
American computer scientist and visual artist Jaron Lanier coined the term “virtual reality” in 1987. Lanier and human-computer interaction pioneer Thomas G. Zimmerman left Atari in 1985 to found VPL Research, the first company to sell VR goggles and wired gloves.
VR provides an immersive sensory experience that digitally simulates environments for applications in entertainment, education, architectural and urban design, engineering and robotics, archaeology and, increasingly, healthcare. Researchers and clinicians are exploring the use of VR to manage psychological and physical conditions including stress, anxiety, depression, dementia, autism, pain management and rehabilitation.
Healthcare providers have sought alternatives to opioids to address chronic pain as opioid addiction and death has become a worldwide crisis. In 2021, the US Food and Drug Administration authorized the marketing of a prescription home-use VR device to manage chronic low back pain.
At the Pain Studies Lab at Simon Fraser University in Vancouver, Dr. Diane Gromala, Canada Research Chair in Computational Technologies for Transforming Pain, leads a research group that conducts patient-centred research to study, invent and design technology systems for people who live with chronic pain. Systems and techniques employed in clinics and in patients’ homes include immersive virtual reality, immersive games, personal data capture and visualization, physiological sensing, wearable computing and mobile technologies and systems.
According to the World Health Organization (WHO), anxiety disorders are the world’s most common mental disorders, affecting 301 million people in 2019. The WHO predicts that by 2030, mental health conditions will be the leading cause of disease burden worldwide. Anxiety has traditionally been treated by a combination of psychotherapy and medication. Virtual reality is now being integrated with traditional therapies, safely immersing patients in a therapeutic environment to practice mindfulness, paced breathing and calming distraction to cope with anxiety and stress.
Virtual Reality for Supporting the Treatment of Depression and Anxiety: Scoping Review, a paper by researchers in New Zealand and China published in the peer-reviewed journal JMIR Mental Health in 2021 noted: “Most studies demonstrated the use of VR to be effective for supporting the treatment of anxiety or depression in a range of settings and recommended its potential as a tool for use in a clinical environment.”
Artificial Intelligence and Machine Learning
From disease detection and treatment recommendations to drug discovery and patient engagement, AI and machine learning promise to be game changers in healthcare. At the same time, governments around the world are concerned about the risks of AI. Representatives from 28 countries from across the globe including Canada, the UK, the US, Africa, the Middle East, Asia and the EU met in the UK in November 2023 and identified, in the Bletchley Declaration, “the urgent need to understand and collectively manage potential risks through a new joint global effort to ensure that AI is developed and deployed in a safe, responsible way for the benefit of the global community.”
The World Health Organization (WHO) has noted that AI tools have the potential to transform the health sector by strengthening clinical trials, improving medical diagnosis and treatment and enhancing the skills of healthcare professionals. In response to the increasing use of AI for health, the WHO has released a new publication listing key regulatory considerations and emphasizing:
the importance of establishing AI systems’ safety and effectiveness;
rapidly making appropriate systems available to those who need them; and
fostering dialogue among stakeholders, including developers, regulators, manufacturers, health workers, and patients.
Enhancing the reliability and accuracy of AI-enabled diagnosis via complementarity-driven deferral to clinicians, a joint paper by Google DeepMind and Google Research published in Nature Medicine in July 2023, proposes Complementarity-driven Deferral-to-Clinical Workflow (CoDoC), an add-on tool for human-AI collaboration that learns when to trust a predictive AI’s diagnosis or defer to a clinician. CoDoC learns to establish the reliability of a predictive AI model as compared to a clinician’s decision and is designed to be used by non-machine learning experts.
According to Krishnamurthy Dvijotham and Taylan Cemgil, on behalf of the CoDoC team, “CoDoC is a promising example of how we can harness the benefits of AI in combination with human strengths and expertise. We are working with external partners to rigorously evaluate our research and the system’s potential benefits. To bring technology like CoDoC safely to real-world medical settings, healthcare providers and manufacturers will also have to understand how clinicians interact differently with AI, and validate systems with specific medical AI tools and settings.”
An example of the use of AI to bring information to patients is AskEllyn.ai, which launched last week in Waterloo. The platform uses generative artificial intelligence to help people get answers to their questions about breast cancer diagnosis and treatment. AskEllyn was developed by Ellyn Winters-Robinson, using stories from her book Flat Please – Hold The Shame as the base for its large language model, in collaboration with Pat Belliveau, CEO of Catalyst Entertainment, marketing pro Ryan Burgio and software developer Christian Silvestru. For external resources, Winters-Robinson curated a list of third-party sites that the tool will recommend. Users are able to chat with Ellyn anytime, anywhere, and in any language to ask questions ranging from what to expect from chemotherapy to how to speak with friends and family about a diagnosis.
“AskEllyn is there to answer the thousands of questions patients have that doctors simply don’t have the time to answer,” says Winters-Robinson. She envisions the project as the first instance of Conversation Care, a new kind of healthcare that could include platforms for information about a range of conditions “so that no one diagnosed will ever walk alone,” she says.
Precision Medicine
Precision or personalized medicine is defined by the National Institutes of Health (NIH) as “an innovative approach that takes into account individual differences in patients’ genes, environments, and lifestyles.”
This approach to treatment is applied by oncologists to classify cancers into precise types and subtypes and to choose treatments based on the DNA signature of an individual patient’s tumor. Oncologists also use cancer immunotherapy through the use of the patient’s immune system to stop or slow the growth of cancer, stop cancer from spreading to other parts of the body, help the immune system work better to destroy cancer cells and deliver toxins, such as radiation or chemotherapy, directly to cancer cells.
Another form of precision medicine is pharmacogenetics, a field of research at the crossroads of pharmaceuticals and genetics and a rapidly growing field in human genetics. Pharmacogenetics studies how a person’s genes affect how they respond to medications in order to help clinicians prescribe the drugs and doses best suited for each patient. Pharmacogenetics is also expected to contribute to advanced screening for disease, providing people with the opportunity to make lifestyle and environmental changes at an early age in order to avoid or lessen the severity of a genetic disease.
Precision medicine is also emerging as a course for identifying therapies for the 6,000–8,000 identified unique rare diseases, with approximately 80% of those diseases being genetic in origin. According to the paper Rare disease emerging as a global public health priority, published in Frontiers of Public Health in 2022, 3.5–5.9% of the world’s population, which corresponds to 263 to 446 million people worldwide, are affected by rare diseases.
In Canada, All for One, a pan-Canadian initiative, was launched in 2022 to increase access to genome-wide sequencing for diagnosis and treatment of genetic diseases. Led by Genome Canada, the initiative provides access to genome-wide sequencing for diagnosis and treatment of life-threatening genetic diseases. A key component of the All for One precision health initiative is the development of a Pan-Canadian Health Data Ecosystem, which connects and leverages genomic data across clinical sites to drive research breakthroughs in order to improve patient care. The ecosystem will enable data sharing between institutions, across jurisdictional boundaries, and between clinical and research settings, serving as a data solution to deliver precision health for rare genetic diseases.
In the US, Vertex Exa-cel therapy, a treatment and potential cure for sickle cell disease has been found safe enough for clinical use and may receive federal approval this year. Sickle cell disease, an illness that afflicts more than 100,000 Americans, affects millions of people worldwide, most of whom have African ancestry. Caused by a gene mutation, the disease results in strokes, organ damage and episodes of severe pain. If approved, this treatment would be the first medicine to treat a genetic disease using CRISPR gene-editing.
Researcher Spotlight: Laura Hopkins
Dr. Laura Hopkins Gynecologic Oncologist, Saskatchewan Cancer Agency Professor, College of Medicine, Division of Oncology, University of Saskatchewan Provincial Lead for Gynecologic Oncology
Laura Hopkins always knew she wanted to be a doctor. Growing up on a beef cattle farm north of Napanee, Ontario, she enjoyed sewing, knitting and making lace. She attributes her proficiency as a surgeon to the eye-hand coordination she developed doing these crafts.
After completing medical school at the University of Toronto, Laura trained as a resident at McMaster University, where evidence-based medicine was first practiced. Described as one of the most important medical advances in the past 150 years, evidence-based medicine integrates the best research data with clinical expertise and patient values in order to use the best evidence to give patients the best possible care. Laura wanted to focus on clinical care and loved doing quality assurance projects to answer questions about how patient care could be improved. Her work to acquire evidence on how the use of antibiotics prior to cesarean delivery and the prophylactic prescription of anti-clotting agents for all cancer in-patients improved infection and clot rates was very rewarding – for Laura and for the patients who benefitted from these projects.
Laura sampled the field of electives during her residency and it was an obstetrician-gynecologist who served as the role model that led her to specialize in obstetrics and gynecology. “She was the first happy doctor I had met,” says Laura. “I never looked back after working with her.”
Laura was on a path to a career as a generalist obstetrician-gynecologist when she was encouraged to apply for a fellowship in gynecologic oncology. Gynecologic oncologists treat ovarian, cervical, uterine, and vulvar cancers and are a unique class of physicians who not only perform complex surgeries but also work with women through their entire course of treatment, including chemotherapy and palliative support. She was accepted to the program at the University of Toronto and says, “It was the right decision and best choice for me. There is immediate gratification in getting rid of a bad problem for a patient through surgery.”
Laura was recruited to Saskatchewan in September 2019 after 18 years at the Ottawa Hospital and the Faculty of Medicine at the University of Ottawa. During her tenure at the University of Ottawa, she published papers, participated in committee work and served as undergraduate director, post-graduate director and division head. After almost two decades of this work, she looked for a change from the focus on medical education and started doing locums, covering for physicians on leave in Halifax and Saskatoon.
In late 2018, Saskatoon lost both of its gynecological oncologists due to exhausting workloads that resulted in burnout. Another resigned in Regina in June 2019, leaving just one permanent gynecological oncologist practicing in Saskatchewan. When the province began recruiting new physicians, Laura expressed interest and was hired as program lead to create a provincial model of care guidelines, quality improvement initiatives and clinical trials. She set up clinical programs in Saskatoon and Regina, and hired five additional gynecological oncologists to staff those programs. She opened clinical trials for women with cancer for the first time in Saskatchewan, achieved the best surgical wait times for gynecologic cancer in Canada, and inaugurated a robotic surgery program. With research funding provided by the federal government, matched by the provincial government and made available through Ovarian Cancer Canada, Laura set up a biobank for ovarian tumor tissue and an academic program.
In September 2023, Laura launched the Saskatchewan Cancer Agency’s first investigator-initiated trial. This is the first pragmatic trial in Canada that will feature patients, oncologists, pathologists and scientists working together to deliver personalized treatment options and improve quality of life. Ovarian cancer patients’ tumors will be tested for mutations that predict response to a new class of drugs, providing accurate, personalized, genomic information about each patient’s tumor and helping patients make informed choices about their care. A total of 100 patients from across Saskatchewan will be enrolled in the 2.5-year trial. “For the first time, we will be able to give ovarian cancer patients very specific information about their chances of responding to treatment,” notes Laura. “When I was in training, we used to talk about “bench to bedside” and cutting-edge care. But I was trained to guess about what chemo drugs were going to work and in what order to administer those drugs. Now we work with scientists who can run a 1,200-drug panel against cancer cells to find the right drugs to kill those cells.”
Laura Hopkins holds nearly $5 million in active research grants spanning surgical quality and safety, precision medicine and new technologies in oncofertility. She is a clinician, educator, researcher and successful leader in building a strong gynecological oncology clinical and research program and team in Saskatchewan. Patient care remains her priority. “My passion is to provide excellent, compassionate, timely care for my patients through all stages of treatment,” she says.
CANARIE connects Canada to the world with programs that equip researchers, students, and start-ups in Canada to excel on the global stage. Established in 1993 by the Government of Canada as a non-profit corporation to advance Canada’s knowledge and innovation infrastructure, the organization’s priorities, as established by Innovation, Science and Development Canada, are to:
Provide an internationally competitive ultra-high-speed network for Canada’s research, innovation and advanced education communities;
Develop, demonstrate and implement next-generation technologies;
Bolster Canada’s technology capabilities by assisting Canadian institutions and companies operating in Canada to advance innovation and commercialization of products and services.
CANARIE members include colleges, universities, healthcare facilities, research and post-secondary institutes, non-profit innovation organizations, government agencies and private sector organizations from across Canada.
“The organization’s mandate has evolved over its 30-year history,” says Kathryn Anthonisen, CANARIE President and CEO. Initiatives led by CANARIE since its inception include:
laying the groundwork, with provincial partner networks, for the first commercial Internet in Canada;
incubating the Internet Registration Authority in Canada, now known as CIRA;
working with global peers to align international research and education infrastructures to support globally collaborative research, now formalized via the Global Network Advancement Group (GNA-G);
developing the grid certificate authority in Canada that provides secure access to data generated from the Large Hadron Collider and other advanced digital technologies;
supporting the uptake of cloud technology by Small and Medium-sized Enterprises (SMEs) in Canada;
identifying gaps in research software and championing the development of powerful research software tools to efficiently enable researchers across many disciplines to accelerate discovery, a program that has transitioned to the Digital Research Alliance of Canada as part of the Digital Research Infrastructure (DRI) Strategy; and
supporting Research Data Canada to align research data activities within Canada and internationally, now transitioned to the Digital Research Alliance of Canada as part of the DRI Strategy.
CANARIE’s current mandate includes enhancement of the cybersecurity capabilities of Canada’s research and education institutions. “The post-secondary education sector is one of the top three targets in Canada for cybersecurity breaches” notes Anthonisen. “Threat actors from nation-states are sophisticated, well-funded, and well-organized. They target research data, intellectual property and infrastructure to disrupt and disable the peace of mind of Canadians,” she says
To address its cybersecurity mandate, CANARIE launched the Cybersecurity Initiatives Program (CIP) in November 2020. 97% of 220 research and post-secondary organizations that are eligible for the program are now participating in the CIP, which offers funded services to strengthen organizations’ cybersecurity capabilities.
As part of this work, CANARIE and its provincial and territorial partners in the National Research and Education Network (NREN) launched a national cybersecurity assessment service, based on the five key dimensions of the U.S. National Institute of Standards and Technology (NIST) Cybersecurity Framework. The goals of the assessment are to provide a clear, comprehensive picture of the cybersecurity maturity of Canada’s research & education sector, and identify risk-based priorities for the planning, investment, and delivery of future cybersecurity initiatives at the organizational, regional, and federal level.
CANARIE, with its partners in the NREN, is also piloting a federated Security Operations Centre for the research and education sector, CanSSOC. Given that many institutions and NREN partners have already invested in cybersecurity expertise, processes and infrastructures, “CANARIE’s goal is to stitch together these existing investments to cost-effectively enable advanced threat detection and response for universities, colleges, polytechnics and CEGEPs across Canada,” says Anthonisen.
To support innovation in the private sector, Canadian companies with fewer than 500 employees have access to CANARIE’s DAIR Cloud Program, which provides resources to assist start-ups and SMEs for rapid and scalable design, development, validation, and demonstration of products and services. Over 1900 start-ups have used the DAIR Cloud program to build and test new products and services. This service is part of CANARIE’s Private Sector Innovation mandate, which recognizes CANARIE’s unique position at the nexus of research, technology, and government policy, and serves to accelerate the adoption of transformative technologies among Canadian businesses.
“CANARIE is an essential service,” notes Sylvie LaPerrière, who serves as Past Chair on the organization’s Board of Directors. “We are very much at the service of the community. We do a lot of listening to uncover future needs. And through this listening comes innovation.”
CANARIE is deeply committed to equity, diversity and inclusion, which is reflected in the diversity of its Board of Directors. The Board of Directors includes members from across Canada, representing research, education and industry from all regions. “A plurality of voices makes the board stronger,” says LaPerrière. “The CANARIE Board, with extensive expertise from both the public and private sectors, strengthens CANARIE’s ability to deliver on its mandate priorities by ensuring a diversity of perspectives that challenge management to maximize the value CANARIE delivers to its stakeholder communities.”
This commitment applies equally to CANARIE’s 84 employees. “When people feel they can bring their whole selves to work, they are able to bring richness and value to the organization,” says Anthonisen.
In late October, Profound Impact founder and CEO, Sherry Shannon-Vanstone, was appointed as the Vice Chair of the CANARIE board working with the newly appointed Chair, Larry Rosia, President of Saskatchewan Polytechnic, and Past Chair, Sylvie LaPerrière.
Sherry’s appointment as Vice Chair of the CANARIE board reflects the significant contributions she has made to a range of industries, including cryptography, information security, and telecommunications as well as her dedication to the advancement of women in technology. “I look forward to working with my fellow board members to strengthen Canada’s national digital infrastructure and ensure our country continues to inspire ground-breaking innovations and remain globally competitive,” she says.
Dr. Harald Stöver Founder and CEO, Allarta Life Science Professor, McMaster University
It was the influence and encouragement of a high school science teacher and the chemistry set handed down by his older brother that first triggered Dr. Harald Stöver’s interest in science. “I had a tiny lab in our house where I carried out chemical reactions and experimented with fireworks – including an unsuccessful attempt to blow up a tree stump. My parents were very supportive of my hobby, except perhaps for that tree stump. My mother even helped me conduct science experiments in the family kitchen,” recalls Harald.
Harald Stöver had completed three years of undergraduate chemistry study at the Technische Universitat Darmstadt in his native Germany when he decided to move to Canada for a year. His plan was to complete his degree at the University of Ottawa and return to Germany. However, his academic advisors in Ottawa noted that Harald’s undergraduate work from Darmstadt qualified him to enter graduate school. He became the first graduate student of the late Christian Detellier and completed his Ph.D. at the University of Ottawa. “Canada was now my home. They captured me!” says Harald.
During his time at the University of Ottawa, Harald established a connection with Professor Jean Fréchet, a professor in polymer chemistry. When Professor Fréchet moved to Cornell University as IBM Professor of Polymer Chemistry, he invited Harald to join him as a postdoctoral fellow to start research on a new technique. “We did great work together. I felt comfortable setting up new labs. After all, I had practiced in my mother’s kitchen,” says Harald.
Harald is currently a professor of chemistry and chemical biology in the Faculty of Science at McMaster University. During his tenure of more than three decades at McMaster, he has established a reputation as a leading researcher in polymer hydrogels, bio-relevant macromolecules and the delivery of biologics. His research and work with industry has been recognized by being named an NSERC/3M Industrial Research Chair, receiving Canada’s National Macromolecular Science and Engineering Award, and his appointment as Director of the NSERC Collaborative Research and Training Experience (CREATE) Program in Biomaterials.
When McMaster University decided to expand its focus on teaching and research to include entrepreneurship, Harald’s experience and affinity for working with industry made him a clear choice for the university to invest in transferring his research to market. Allarta Life Science, a pre-clinical life science company that develops next-generation biomaterials for immune-privileged delivery of cells, stem cells and biologics, was launched in 2019 by Harald Stöver and Maria Antonakos, a senior executive with a broad range of experience managing innovation, and with an equity investment by McMaster.
Allarta Life Science’s work is poised to fundamentally change the way that patients with Type 1 Diabetes (T1D), a chronic disease that comes with a host of potential complications, including increased risk of stroke and heart attack, receive treatment.
Patients with advanced T1D are eligible for islet cell transplants from the pancreas of a deceased donor. However, this alternative to multiple daily injections of insulin to manage blood sugar comes with costs to patients’ health. Because the body identifies the transplanted cells as invaders, patients must take immune suppression drugs for the rest of their lives. The solution being developed by Allarta Life Science is an immune-protective polymer gel, not recognized by the body as foreign material, to encapsulate the islet cells while still allowing the cells to receive nutrients and release insulin by diffusion. Harald likens the gel to a diver’s shark cage that protects a human from attack while allowing water to pass through. Ultimately, this therapy will reduce or eliminate the need for current immune suppression drugs that leave patients at risk for infections.
As a vertically integrated company, Allarta Life Sciences also works with partners who develop stem cell-based therapeutic cells that would eliminate the need for donor transplants. Fewer than a dozen other companies work in this area. Some develop new cells not recognized by the immune system, others focus on the immune-protective barrier. Allarta is unique in that their work covers all bases by producing hydrogels that contain islet cells, allow diffusion of insulin and deflect the immune system. “We expect to work with human subjects in clinical trials within two years,” notes Harald.
In October 2023, Allarta announced news of an award from JDRF, the leading global T1D research and advocacy organization, to fund the company’s ongoing work. “The JDRF award will help us advance these therapies further towards the clinic,” Harald says.
Harald is excited to be part of McMaster University’s evolution of academic focus to include building the entrepreneurial sector. “This brings fundamental science developed in university labs to clinical settings. It’s good for undergraduate and graduate students and for faculty and gives back to the community,” he explained.
Harald Stöver has come a long way from the experiments he conducted in his home science lab and his mother’s kitchen. His ground-breaking research at McMaster University and the work of Allarta Life Sciences are poised to make a profound impact by improving the lives of Type 1 Diabetes patients worldwide.
You can learn more about Harald in the visualizations below.
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September was a month of celebration and new partnerships at Profound Impact.
We were proud to name Hui Huang Hoe and Mike Farwell as winners of the 2023 Impactful Actions Awards on September 14, Profound Impact Day.
Profound Impact Day is a time to recognize the world’s diverse leaders and changemakers who are leaving their mark on the global community through their initiatives, influence, and impact. This year the award expanded to include two categories: Young Leader and Lifetime Achievement. Hoe was awarded the Young Leader category, and Farwell accepted the Lifetime Achievement award.
Hui Huang Hoe is a serial inventor of green electrochemistry and the founder of elerGreen, a cleantech startup recovering valuable polymers, metals and chemicals from chemical waste.
Mike Farwell is a radio host at CityNews 570 in Kitchener and is play-by-play announcer for the Kitchener Rangers OHL hockey team. He is a relentless community builder who turned the grief from losing his two sisters to cystic fibrosis into Farwell4Hire, the largest annual fundraiser for Cystic Fibrosis Canada, through which he has raised more than $1.25 million.
You’ll learn more about Hui Huang and Mike in the profiles in this month’s newsletter.
We were also pleased to announce a new partnership with Haltech Regional Innovation Centre in September. Haltech is a non-profit organization launched in 2011 and is the go-to strategic connector and educator for start-ups in the Halton Region of Ontario and beyond. The partnership between Profound Impact and Haltech is designed to discover a range of funding and research opportunities for internal research and product development for Haltech’s clients through access to Research Impact, our AI-powered tool.
Profound Impact is proud to be a woman-founded and led company. Last month, I joined Sean Weisbrot, host of the We Live to Build podcast, to talk about my previous career in cryptography, my ongoing passion for encouraging women in business and the power of female investors. You’ll find the podcast here.
Thank you for connecting with us and the Profound Impact community.
